A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration
نویسندگان
چکیده
منابع مشابه
Dopaminergic neurons modulate GABA neuron migration in the embryonic midbrain.
Neuronal migration, a key event during brain development, remains largely unexplored in the mesencephalon, where dopaminergic (DA) and GABA neurons constitute two major neuronal populations. Here we study the migrational trajectories of DA and GABA neurons and show that they occupy ventral mesencephalic territory in a temporally and spatially specific manner. Our results from the Pitx3-deficien...
متن کاملDopaminergic neurons modulate GABA neuron migration in the embryonic midbrain
INTRODUCTION Neuronal migration is a fundamental process in the development of the central nervous system because neurons eventually dwell in regions distinct from their origin. From ventricular zones, neurons and/or neuronal progenitors navigate along diverse courses, radially and tangentially, to their final destination and integrate into specific brain circuits (Corbin et al., 2001; Hatten, ...
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During neurogenesis, generation, migration and integration of the correct numbers of each neuron sub-type depends on complex molecular interactions in space and time. MicroRNAs represent a key control level allowing the flexibility and stability needed for this process. Insight into the role of this regulatory pathway in the brain is still limited. We performed a sequential experimental approac...
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Loss of midbrain dopaminergic (mDA) neurons underlies the motor symptoms of Parkinson's disease. Towards cell replacement, studies have focused on mechanisms underlying embryonic mDA production, as a rational basis for deriving mDA neurons from stem cells. We will review studies of β-catenin, an obligate component of the Wnt cascade that is critical to mDA specification and neurogenesis. mDA ne...
متن کاملmiR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition
During neurogenesis, generation, migration and integration of the correct numbers of each neuron subtype depends on complex molecular interactions in space and time. MicroRNAs represent a key control level allowing the flexibility and stability needed for this process. Insight into the role of this regulatory pathway in the brain is still limited. We performed a sequential experimental approach...
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ژورنال
عنوان ژورنال: Communications Biology
سال: 2018
ISSN: 2399-3642
DOI: 10.1038/s42003-018-0080-0